By Philips ∙ Aug 06, 2019 ∙ 2 min read
Clinical studies demonstrate that physiologic lesion assessment to determine lesion significance and guide revascularization decisions is superior to angiographically guided treatment, and benefits patients with reduced rates of cardiac events.1,2 Philips provides you the opportunity to use one of two clinically validated indices: iFR or FFR.
FFR and iFR can be obtained during routine coronary angiography by using a pressure wire to calculate the ratio between coronary pressure distal to a stenosis and the aortic pressure proximal. When resistance is constant, this ratio represents the potential decrease in coronary flow distal to the coronary stenosis.
The FFR modality uses hyperemic agents to achieve a state of constant resistance.
Pressure = flow x resistance
Fundamental equation for relating pressure flow derived from Poiseuille's Law for fluid dynamics
The iFR modality measures pressure during the wave-free period of the cardiac cycle when resistance is naturally constant.
Unlike FFR, iFR does not require administration of vasodilators because hyperemia is not necessary when measuring pressure during the wave-free period of the cardiac cycle.
iFR is a Class 1A recommendation and is proven to reduce procedure time, patient discomfort and cost compared to FFR. 2,3,4
The iFR modality provides a hyperemia-free measurement in as few as five heartbeats.
Both DEFINE FLAIR and iFR Swedeheart were designed with the dichotomous cut-point of iFR in the iFR arm.3,4 With comparable MACE rates to FFR, these results mean the 0.89 cut-point for iFR is proven and backed by more than 4500 patients of outcome data.
FFR ischemia scale
An FFR lower than .80 is generally considered to be associated with myocardial ischemia.
1. Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213–24. 2. Berntorp K, et al. Instantaneous wave-free ratio compared with fractional flow reserve in PCI: A cot-minimization analysis. Int J Cardiol 2021 1;344:54·59 3. Davies JE, et al., Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI. N Engl J Med. 2017 May 11;376(19):1824-1834. 4. Gotberg M, et al., iFR-SWEDEHEART Investigators. Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI. N Engl J Med. 2017 May 11;376(19):1813-18233. 5. 2024 ESC Guidelines for the management of chronic coronary syndromes: Developed by the task force for the management of chronic coronary syndromes of the European. Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS), European Heart Journal, 2024;, ehae177. Always read the label and follow the directions for use.Philips medical devices should only be used by physicians and teams trained in interventional techniques, including training in the use of this device.Products subject to country availability. Please contact your local sales representative. ©2024 Koniklijke Philips N.V. All rights reserved. Trademarks are the property of Koninklijke Philips N.V. or their respective owners. Philips reserves the right to change product specifications without prior notification.
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